Michael Seiler

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler, Akihide Yoshimi, Rachel Darman et al. · Nature Medicine · 2018 · 510 citations · Full text

Life Sciences, Molecular Biology, Oncology +15

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Michael Seiler, Shouyong Peng, Anant A. Agrawal et al. · Cell Reports · 2018 · 475 citations · Full text

Life Sciences, Genetics, Oncology +17

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Rachel Darman, Michael Seiler, Anant A. Agrawal et al. · Cell Reports · 2015 · 463 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

Esther A. Obeng, Ryan Chappell, Michael Seiler et al. · Cancer Cell · 2016 · 386 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13

Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns

A. Rose Brannon, Anupama Reddy, Michael Seiler et al. · Genes & Cancer · 2010 · 332 citations · Full text

Medicine, Cancer Biology, Oncology +17