Haile Tecle

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Judith S. Sebolt–Leopold, David T. Dudley, Román Herrera et al. · Nature Medicine · 1999 · 965 citations

Colon Tumors, Medicine, Receptor Tyrosine Kinase +9

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 612 citations

Signal Transduction, Signaling Pathway, Cell Regulation +8

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Stephen D. Barrett, Alexander J. Bridges, David T. Dudley et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 280 citations

Medicinal Chemistry, Drug Target, Biochemistry +10

4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties

Juan C. Jaén, Lawrence D. Wise, Bradley W. Caprathe et al. · Journal of Medicinal Chemistry · 1990 · 254 citations · Full text

Active Dopamine, Organic Chemistry, Pharmacotherapy +18

Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Andrea J. Gonzales, Kenneth E. Hook, Irene W. Althaus et al. · Molecular Cancer Therapeutics · 2008 · 220 citations · Full text