Irene W. Althaus

PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with <i>EGFR</i> and <i>ERBB2</i> Mutations that Are Resistant to Gefitinib

Jeffrey A. Engelman, Kreshnik Zejnullahu, Christopher-Michael Gale et al. · Cancer Research · 2007 · 713 citations · Full text

Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function

Benjamin L. Allen, Jane Y. Song, Luisa Izzi et al. · Developmental Cell · 2011 · 289 citations · Full text

Protein Function, Signal Transduction, Molecular Physiology +11

Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Andrea J. Gonzales, Kenneth E. Hook, Irene W. Althaus et al. · Molecular Cancer Therapeutics · 2008 · 220 citations · Full text

Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E.

Irene W. Althaus, James J. Chou, Andrea J. Gonzales et al. · Journal of Biological Chemistry · 1993 · 164 citations · Full text

Steady-state Kinetic Studies, Biochemistry, Natural Sciences +15

The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

Irene W. Althaus, Andrea J. Gonzales, James J. Chou et al. · Journal of Biological Chemistry · 1993 · 162 citations · Full text

Viral Replication, Potent Inhibitor, Immunology +19