Jing Yuan

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Silvia Buonamici, Juliet Williams, Michael Morrissey et al. · Science Translational Medicine · 2010 · 553 citations

Hrp pilus: An <i>hrp</i> -dependent bacterial surface appendage produced by <i>Pseudomonas syringae</i> pv. <i>tomato</i>  DC3000

Elina Roine, Wensheng Wei, Jing Yuan et al. · Proceedings of the National Academy of Sciences · 1997 · 355 citations · Full text

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Shifeng Pan, Xu Wu, Jiqing Jiang et al. · ACS Medicinal Chemistry Letters · 2010 · 325 citations · Full text

Selective Smoothened Antagonist, Chemoprevention Strategy, Novel Therapy +14

A crucial requirement for Hedgehog signaling in small cell lung cancer

Luciano G. Martelotto, Martin Peifer, Martin L. Sos et al. · Nature Medicine · 2011 · 246 citations

Tumor Biology, Oncology, Medicine +8