Xu Wu

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Jun Liu, Shifeng Pan, Mindy H. Hsieh et al. · Proceedings of the National Academy of Sciences · 2013 · 819 citations · Full text

Wnt Signaling, Tumor Biology, Signaling Pathway +19

A Stem Cell–Based Approach to Cartilage Repair

Kristen Johnson, Shoutian Zhu, Matthew S. Tremblay et al. · Science · 2012 · 774 citations

Tissue Engineering, Small Molecule Kartogenin, Bone Repair +19

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Silvia Buonamici, Juliet Williams, Michael Morrissey et al. · Science Translational Medicine · 2010 · 553 citations

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Shifeng Pan, Xu Wu, Jiqing Jiang et al. · ACS Medicinal Chemistry Letters · 2010 · 325 citations · Full text

Selective Smoothened Antagonist, Chemoprevention Strategy, Novel Therapy +14

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Lizhi He, Jhih-Hua Jhong, Qi Chen et al. · Cell Reports · 2021 · 321 citations · Full text