Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Jun Liu, Shifeng Pan, Mindy H. Hsieh, +33

Proceedings of the National Academy of Sciences

Wnt SignalingTumor BiologySignaling PathwayReceptor Tyrosine KinaseHuman Head +17

A Stem Cell–Based Approach to Cartilage Repair

Kristen Johnson, Shoutian Zhu, Matthew S. Tremblay, +8

Science

Tissue EngineeringSmall Molecule KartogeninBone RepairStem Cell BiologyOrthopaedic Surgery +17

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Silvia Buonamici, Juliet Williams, Michael Morrissey, +24

Science Translational Medicine

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

Shifeng Pan, Xu Wu, Jiqing Jiang, +25

ACS Medicinal Chemistry Letters

Selective Smoothened AntagonistChemoprevention StrategyNovel TherapyFunctional SelectivityMedicine +12

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Lizhi He, Jhih-Hua Jhong, Qi Chen, +9

Cell Reports

The Renewal and Differentiation of Isl1+ Cardiovascular Progenitors Are Controlled by a Wnt/β-Catenin Pathway

Yibing Qyang, Silvia Martı́n-Puig, Murali Chiravuri, +17

Cell stem cell

Cardiac MuscleDevelopmental BiologyCardiac ReprogrammingCardiovascular DiseaseSignaling Pathway +8

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

Michael DeRan, Jiayi Yang, Che‐Hung Shen, +10

Cell Reports

Dedifferentiation of Lineage-Committed Cells by a Small Molecule

Shuibing Chen, Qisheng Zhang, Xu Wu, +2

Journal of the American Chemical Society

Combinatorial LibrariesStem Cell BiologyCellular DedifferentiationCellular PhysiologyRegenerative Medicine +14

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

PuiYee Chan, Xiao Han, Baohui Zheng, +7

Nature Chemical Biology

Transcriptional RegulationTead ProteinsSignal TransductionHippo PathwaySignaling Pathway +10

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

Eric J Miller, Jiayi Yang, Michael DeRan, +6

Chemistry & Biology

Signal TransductionBiochemistrySmall Molecule RegulatorMedicineNatural Sciences +8