The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

Andrew A. Wylie, Joseph Schoepfer, Wolfgang Jahnke, +25

Nature

Molecular PharmacologyDrug TargetMedicineImmunologyAllosteric Inhibitor Abl001 +1

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

Eun Hee Kim, Janine O. Ilagan, Yang Liang, +22

Cancer Cell

Genome InstabilitySomatic VariantGeneticsExon RecognitionSrsf2 Mutations Contribute +6

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

Silvia Buonamici, Juliet Williams, Michael Morrissey, +24

Science Translational Medicine

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler, Akihide Yoshimi, Rachel Darman, +33

Nature Medicine

Tumor BiologyMedicineRna SplicingInduces LethalityCell Biology +7

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

Benjamin J. Thompson, Silvia Buonamici, Maria Luisa Sulis, +5

The Journal of Experimental Medicine

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Rachel Darman, Michael Seiler, Anant A. Agrawal, +33

Cell Reports

GeneticsRna SplicingMolecular BiologyMolecular GeneticsCancer Biology +15

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1

Joseph Schoepfer, Wolfgang Jahnke, Giuliano Berellini, +24

Journal of Medicinal Chemistry

Drug TargetMixed-phenotype Acute LeukemiaMolecular BiologyTumor BiologyMyeloid Neoplasia +14

Physiologic Expression of Sf3b1 K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

Esther A. Obeng, Ryan Chappell, Michael Seiler, +17

Cancer Cell

Signaling PathwayAberrant SplicingReceptor Tyrosine KinasePathologyCellular Biology +5

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

Apostolos Klinakis, Camille Lobry, Omar Abdel‐Wahab, +16

Nature

Hematological MalignancyTumor BiologyHematologyMyeloid NeoplasiaMyelopoiesis +8

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

Stanley Chun-Wei Lee, Heidi Dvinge, Eun Hee Kim, +19

Nature Medicine

Hematological MalignancyRna ProcessingSystems BiologyMixed-phenotype Acute LeukemiaMalignant Blood Disorder +5