Erli Zhang

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

Life Sciences, Biochemistry, Molecular Biology +9

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 67 citations

Medicine, Medicinal Chemistry, Pharmacology +9

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors

Noel A. Powell, Fred L. Ciske, Cuiman Cai et al. · Bioorganic & Medicinal Chemistry · 2007 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Binding thermodynamics of substituted diaminopyrimidine renin inhibitors

Ronald W. Sarver, Jeanette Peevers, Wayne L. Cody et al. · Analytical Biochemistry · 2006 · 41 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

The Discovery of (2<i>R</i>,4<i>R</i>)‐<i>N</i>‐(4‐chlorophenyl)‐<i>N</i>‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2<i>H</i>)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Jeffrey T. Kohrt, Christopher F. Bigge, John W. Bryant et al. · Chemical Biology & Drug Design · 2007 · 39 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9