Christopher F. Bigge

Subtype-Selective <i>N</i>-Methyl-<scp>d</scp>-aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines

Jon L. Wright, Tracy F. Gregory, Christopher F. Bigge et al. · Journal of Medicinal Chemistry · 1999 · 95 citations · Full text

Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists

Daniel F. Ortwine, Thomas C. Malone, Christopher F. Bigge et al. · Journal of Medicinal Chemistry · 1992 · 64 citations

Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists

Christopher F. Bigge, Graham Johnson, Daniel F. Ortwine et al. · Journal of Medicinal Chemistry · 1992 · 59 citations

Pharmaceutical Science, Receptor Antagonists, Pharmacotherapy +20

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity

Christopher F. Bigge, Thomas C. Malone, Peter A. Boxer et al. · Journal of Medicinal Chemistry · 1995 · 58 citations · Full text

Medicinal Chemistry, Functional Selectivity, Medicine +15

Palladium-catalyzed coupling reactions of uracil nucleosides and nucleotides

Christopher F. Bigge, Panos Kalaritis, Joanne R. Deck et al. · Journal of the American Chemical Society · 1980 · 56 citations

Cross-coupling Reaction, Molecular Sciences, Bioorganic Chemistry +13