Concepedia

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors

Noel A. Powell, Fred L. Ciske, Cuiman Cai, Daniel D. Holsworth, Ken Mennen, Chad A. Van Huis, Mehran Jalaie, Jacqueline E. Day, Michelle Mastronardi, Pat McConnell,

Bioorganic & Medicinal Chemistry · 2007 · 52 citations · 20 references

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20

The maximal affinity of ligands

Irwin D. Kuntz, K. Chen, Kim A. Sharp et al. · Proceedings of the National Academy of Sciences · 1999 · 845 citations

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Aliskiren, a Novel Orally Effective Renin Inhibitor, Provides Dose-Dependent Antihypertensive Efficacy and Placebo-Like Tolerability in Hypertensive Patients

Alan H. Gradman, Roland E. Schmieder, R. Lins et al. · Circulation · 2005 · 524 citations

, , +17

Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette M. Wood, Jürgen Maibaum, Joseph Rahuel et al. · Biochemical and Biophysical Research Communications · 2003 · 503 citations

, , +14

Blood Pressure Lowering in Essential Hypertension With an Oral Renin Inhibitor, Aliskiren

Alice Stanton, C. Jensen, Juerg Nussberger et al. · Hypertension · 2003 · 341 citations

, , +17

Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats

Bernhard Pilz, Erdenechimeg Shagdarsuren, Maren Wellner et al. · Hypertension · 2005 · 246 citations · Full text

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