Chad A. Van Huis

A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

Kevin J. Filipski, Jeffrey T. Kohrt, Agustin Casimiro‐Garcia et al. · Tetrahedron Letters · 2006 · 56 citations

Aryl Halides, Chemical Engineering, Cross-coupling Reaction +7

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors

Noel A. Powell, Fred L. Ciske, Cuiman Cai et al. · Bioorganic & Medicinal Chemistry · 2007 · 52 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Rational Design +6

Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors

Danette A. Dudley, Amy Bunker, Liguo Chi et al. · Journal of Medicinal Chemistry · 2000 · 49 citations · Full text

Combinatorial Chemistry, Inappropriate Thrombus Formation, Organic Chemistry +17

Binding thermodynamics of substituted diaminopyrimidine renin inhibitors

Ronald W. Sarver, Jeanette Peevers, Wayne L. Cody et al. · Analytical Biochemistry · 2006 · 41 citations · Full text

Biochemistry, Natural Sciences, Medicine +7

The Discovery of (2<i>R</i>,4<i>R</i>)‐<i>N</i>‐(4‐chlorophenyl)‐<i>N</i>‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2<i>H</i>)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Jeffrey T. Kohrt, Christopher F. Bigge, John W. Bryant et al. · Chemical Biology & Drug Design · 2007 · 39 citations

Pharmaceutical Science, Pharmacotherapy, Chemical Biology +16