A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

Kevin J. Filipski, Jeffrey T. Kohrt, Agustin Casimiro‐Garcia, +9

Tetrahedron Letters

Aryl HalidesChemical EngineeringCross-coupling ReactionEngineeringOrganic Chemistry +5

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors

Noel A. Powell, Fred L. Ciske, Cuiman Cai, +16

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryRational DesignNatural SciencesMedicine +4

Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors

Danette A. Dudley, Amy Bunker, Liguo Chi, +11

Journal of Medicinal Chemistry

Combinatorial ChemistryInappropriate Thrombus FormationOrganic ChemistryHeterocycle ChemistryMolecular Pharmacology +15

Binding thermodynamics of substituted diaminopyrimidine renin inhibitors

Ronald W. Sarver, Jeanette Peevers, Wayne L. Cody, +14

Analytical Biochemistry

BiochemistryNatural SciencesMedicineMechanism Of ActionChemical Biology +5

The Discovery of (2<i>R</i>,4<i>R</i>)‐<i>N</i>‐(4‐chlorophenyl)‐<i>N</i>‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2<i>H</i>)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Jeffrey T. Kohrt, Christopher F. Bigge, John W. Bryant, +19

Chemical Biology & Drug Design

Pharmaceutical SciencePharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +14

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Jeffrey T. Kohrt, Kevin J. Filipski, Wayne L. Cody, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryFluoropyridine-based InhibitorsBiochemistryMedicineNatural Sciences +9

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer

Thomas D. Aicher, Chad A. Van Huis, Alexander R. Hurd, +23

Journal of Medicinal Chemistry

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

Chad A. Van Huis, Agustin Casimiro‐Garcia, Christopher F. Bigge, +14

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyAnti-cancer Agent +6

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

Jeffrey T. Kohrt, Kevin J. Filipski, Wayne L. Cody, +10

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryFluoropyridine-based InhibitorsBiochemistryMedicine +10

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

Wayne L. Cody, Cuiman Cai, Annette M. Doherty, +10

Bioorganic & Medicinal Chemistry Letters

ThrombosisMedicinal ChemistryPart 1BiochemistryPiperazinedione Template +12