Agustin Casimiro‐Garcia

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

Jean‐Baptiste Telliez, Martin E. Dowty, Lu Wang et al. · ACS Chemical Biology · 2016 · 187 citations · Full text

Jak1 Inhibition, Immunology, Immune Regulation +30

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2<i>S</i>,5<i>R</i>)-5-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Atli Thorarensen, Martin E. Dowty, Mary Ellen Banker et al. · Journal of Medicinal Chemistry · 2017 · 158 citations · Full text

Specific Inhibitor, Drug Target, Pharmacotherapy +25

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

Agustin Casimiro‐Garcia, John I. Trujillo, F.F. Vajdos et al. · Journal of Medicinal Chemistry · 2018 · 72 citations · Full text

Medicinal Chemistry, Covalent Inhibitors, Pharmaceutical Chemistry +12

ATP-Mediated Kinome Selectivity: The Missing Link in Understanding the Contribution of Individual JAK Kinase Isoforms to Cellular Signaling

Atli Thorarensen, Mary Ellen Banker, Andrew Fensome et al. · ACS Chemical Biology · 2014 · 59 citations

Atp-mediated Kinome Selectivity, Molecular Biology, Cytoskeleton +20

A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

Kevin J. Filipski, Jeffrey T. Kohrt, Agustin Casimiro‐Garcia et al. · Tetrahedron Letters · 2006 · 56 citations

Aryl Halides, Chemical Engineering, Cross-coupling Reaction +7