How to measure and predict the molar absorption coefficient of a protein

C. Nick Pace, F.F. Vajdos, Lanette Fee, +2

Protein Science

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Matthew C. Franklin, Kendall D. Carey, F.F. Vajdos, +3

Cancer Cell

Protein FunctionSignal TransductionSignaling PathwayNatural SciencesReceptor Tyrosine Kinase +7

Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid

Theresa Gamble, F.F. Vajdos, Sanghee Yoo, +4

Cell

Virus StructureCrystal StructureBiochemistryNatural SciencesHuman Retrovirus +7

Structure of the Carboxyl-Terminal Dimerization Domain of the HIV-1 Capsid Protein

Theresa Gamble, Sanghee Yoo, F.F. Vajdos, +6

Science

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

W. Gregory Roberts, Ethan Ung, Pamela Whalen, +21

Cancer Research

Antitumor ActivityCell AdhesionFocal Adhesion PlaquesPharmacotherapyCancer Biology +16

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

Jean‐Baptiste Telliez, Martin E. Dowty, Lu Wang, +33

ACS Chemical Biology

Jak1 InhibitionImmunologyImmune RegulationInnate ImmunityInflammatory Arthritis +28

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold, +30

Journal of Medicinal Chemistry

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2<i>S</i>,5<i>R</i>)-5-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Atli Thorarensen, Martin E. Dowty, Mary Ellen Banker, +24

Journal of Medicinal Chemistry

Specific InhibitorDrug TargetPharmacotherapyChemical BiologyPharmaceutical Chemistry +23

Structural insights into the catalytic mechanism of cyclophilin A

B.R. Howard, F.F. Vajdos, Wesley I. Sundquist, +1

Nature Structural & Molecular Biology

Protein AssemblyBiochemistryNatural SciencesEnzyme CatalysisStructure-function Enzyme Kinetics +2

Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism

Mark Merchant, F.F. Vajdos, Mark Ultsch, +7

Molecular and Cellular Biology