John W. Bryant

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors

Noel A. Powell, Fred L. Ciske, Cuiman Cai et al. · Bioorganic & Medicinal Chemistry · 2007 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

The Discovery of (2<i>R</i>,4<i>R</i>)‐<i>N</i>‐(4‐chlorophenyl)‐<i>N</i>‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2<i>H</i>)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Jeffrey T. Kohrt, Christopher F. Bigge, John W. Bryant et al. · Chemical Biology & Drug Design · 2007 · 39 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Ketopiperazine-based renin inhibitors: Optimization of the “C” ring

Daniel D. Holsworth, Cuiman Cai, Xue‐Min Cheng et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors

Daniel D. Holsworth, Mehran Jalaie, Thomas R. Belliotti et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors

Daniel D. Holsworth, Noel A. Powell, Dennis M. Downing et al. · Bioorganic & Medicinal Chemistry · 2005 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10