Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

Wenjing Liang, Shakti Sagar, Rishith Ravindran, +12

Nature Communications

Profibrillatory Actions of Pinacidil in a Conscious Canine Model of Sudden Coronary Death

Liguo Chi, Andrew C. G. Uprichard, Benedict R. Lucchesi

Journal of Cardiovascular Pharmacology

Design, Synthesis, and Biological Activity of Potent and Selective Inhibitors of Blood Coagulation Factor Xa

J. Adam Willardsen, Danette A. Dudley, Wayne L. Cody, +8

Journal of Medicinal Chemistry

ENTPD-1 disrupts inflammasome IL-1β–driven venous thrombosis

Vinita Yadav, Liguo Chi, Raymond Zhao, +13

Journal of Clinical Investigation

Vascular DiseaseDeep Vein ThrombosisImmunologyPathologyImmune System +19

P2Y1 receptor antagonists as novel antithrombotic agents

Jeffrey A. Pfefferkorn, Chulho Choi, Thomas Winters, +11

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPlatelet Aggregation InhibitorsThrombosisBlood PlateletMedicine +6

Actions of Pinacidil at a Reduced Potassium Concentration

Liguo Chi, Black, Philip I. Kuo, +2

Journal of Cardiovascular Pharmacology

Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy

Siting Zhu, Ze’e Chen, Mason Zhu, +15

Circulation Heart Failure

Rational Design, Synthesis, and Biological Activity of Benzoxazinones as Novel Factor Xa Inhibitors

Danette A. Dudley, Amy Bunker, Liguo Chi, +11

Journal of Medicinal Chemistry

Combinatorial ChemistryInappropriate Thrombus FormationOrganic ChemistryHeterocycle ChemistryMolecular Pharmacology +15

The Discovery of (2<i>R</i>,4<i>R</i>)‐<i>N</i>‐(4‐chlorophenyl)‐<i>N</i>‐ (2‐fluoro‐4‐(2‐oxopyridin‐1(2<i>H</i>)‐yl)phenyl)‐4‐methoxypyrrolidine‐1,2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Jeffrey T. Kohrt, Christopher F. Bigge, John W. Bryant, +19

Chemical Biology & Drug Design

Pharmaceutical SciencePharmacotherapyChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +14

Ranolazine Reduces Remodeling of the Right Ventricle and Provoked Arrhythmias in Rats with Pulmonary Hypertension

John T. Liles, Kirsten Hoyer, J Oliver, +3

Journal of Pharmacology and Experimental Therapeutics