Joseph Rahuel

Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette M. Wood, Jürgen Maibaum, Joseph Rahuel et al. · Biochemical and Biophysical Research Communications · 2003 · 502 citations

Combinatorial Chemistry, Pharmaceutical Science, Biochemistry +7

Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.

M.G. Grütter, J.P. Priestle, Joseph Rahuel et al. · The EMBO Journal · 1990 · 361 citations · Full text

Protein Chemistry, Crystal Structure, Protein Function +8

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum et al. · Chemistry & Biology · 2000 · 320 citations · Full text

Drug Target, Biochemistry, Drug Design +11

The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor

Joseph Rahuel · Journal of Structural Biology · 1991 · 121 citations

Protein Assembly, Biochemistry, Natural Sciences +9

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5( <i>S</i> )-Amino-4( <i>S</i> )-hydroxy-8-phenyl-octanecarboxamides:  The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Jürgen Maibaum, Stefan Stutz, Richard Göschke et al. · Journal of Medicinal Chemistry · 2007 · 95 citations · Full text