Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette M. Wood, Jürgen Maibaum, Joseph Rahuel, +19

Biochemical and Biophysical Research Communications

Combinatorial ChemistryPharmaceutical ScienceBiochemistryMedicineRational Drug Design +5

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum, +8

Chemistry & Biology

Drug TargetBiochemistryDrug DesignActive InhibitorsMedicine +9

Synthesis and biological activity of some transition-state inhibitors of human renin

Peter Bühlmayer, Walter Fuhrer, Richard Göschke, +5

Journal of Medicinal Chemistry

Ring contraction of hydroporphinoid to corrinoid complexes

Vittorio Rasetti, Andreas Pfaltz, Christoph Kratky, +1

Proceedings of the National Academy of Sciences

Novel 2,7-Dialkyl-Substituted 5(<i>S</i>)-Amino-4(<i>S</i>)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin

Richard Göschke, Stefan Stutz, Vittorio Rasetti, +13

Journal of Medicinal Chemistry

HypertensionNovel 2,7-Dialkyl-substituted 5PharmacotherapyPharmaceutical ChemistryBlood Pressure +15

A Synthetic Approach to the Isobacteriochlorin Macrocycle

Franz‐Peter Montforts, Silvio Ofner, Vittorio Rasetti, +4

Angewandte Chemie International Edition in English

Combinatorial ChemistryBiosynthesisBioorganic ChemistryIsobacteriochlorin MacrocycleBiochemistry +11

Aufbau der Ligandsysteme des C, D‐Tetradehydrocorrins und Isobakteriochlorins durch Sulfidkontraktion. Kurzmitteilung

Silvio Ofner, Vittorio Rasetti, Beat Zehnder, +1

Helvetica Chimica Acta

Sulfide ContractionBioorganic ChemistrySulfide Contraction MethodPhotochemistryBiochemistry +8

(A→D)‐Cyclization of a Nickel(<scp>II</scp>) Δ¹⁸‐Dehydro‐1‐methylidene‐1,19‐secocorrinate

Vittorio Rasetti, Bernhard Kräutler, Andreas Pfaltz, +1

Angewandte Chemie International Edition in English

Inorganic ChemistryFundamental SignificanceEngineeringJournal Citation ReportScience Communication +11

Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors

Vittorio Rasetti, N.C. Cohen, H. Rüeger, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +10

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists

David Orain, Silvio Ofner, Manuel Koller, +12

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicine6-Amino Quinazolinedione SulfonamidesMechanism Of Action +4