Richard Göschke

Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette M. Wood, Jürgen Maibaum, Joseph Rahuel et al. · Biochemical and Biophysical Research Communications · 2003 · 502 citations

Combinatorial Chemistry, Pharmaceutical Science, Biochemistry +7

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum et al. · Chemistry & Biology · 2000 · 320 citations · Full text

Drug Target, Biochemistry, Drug Design +11

Synthesis and biological activity of some transition-state inhibitors of human renin

Peter Bühlmayer, Walter Fuhrer, Richard Göschke et al. · Journal of Medicinal Chemistry · 1988 · 111 citations · Full text

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5( <i>S</i> )-Amino-4( <i>S</i> )-hydroxy-8-phenyl-octanecarboxamides:  The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Jürgen Maibaum, Stefan Stutz, Richard Göschke et al. · Journal of Medicinal Chemistry · 2007 · 95 citations · Full text

Total synthesis of the calycanthaceous alkaloids

James B. Hendrickson, Richard Göschke, R. W. Rees · Tetrahedron · 1964 · 91 citations

Total Synthesis, Pharmacology, Synthetic Chemistry +2