Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum, +8

Chemistry & Biology

Drug TargetBiochemistryDrug DesignActive InhibitorsMedicine +9

Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor.

Leoluca Criscione, Pascal Rigollier, Christine Batzl‐Hartmann, +13

Journal of Clinical Investigation

NutritionNew Neuropeptide YFood IntakeSocial SciencesGastrointestinal Peptide Hormone +20

Synthesis and biological activity of some transition-state inhibitors of human renin

Peter Bühlmayer, Walter Fuhrer, Richard Göschke, +5

Journal of Medicinal Chemistry

General strategies for the synthesis of indole alkaloids. Total synthesis of (.+-.)-reserpine and (.+-.)-.alpha.-yohimbine

Stephen F. Martin, H. Rüeger, Sidney Williamson, +1

Journal of the American Chemical Society

General StrategiesNatural Product SynthesisNatural SciencesDiversity-oriented SynthesisTotal Synthesis +8

Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites

Ping Du, John Salon, Joseph A. Tamm, +16

Protein Engineering Design and Selection

Signal TransductionBiochemistryFunctional SelectivityMedicineG Protein-coupled Receptor +12

CGP 38 560: orally active, low-molecular-weight renin inhibitor with high potency and specificity.

J M Wood, Leoluca Criscione, Marc de Gasparo, +5

PubMed

HypertensionPharmacotherapyCgp 38Experimental PharmacologyMolecular Pharmacology +15

Application of reductive, single electron transfer processes to the generation and cyclization of ω-unsaturated α-amino radicals

Stephen F. Martin, Chih-Ping Yang, William L. Laswell, +1

Tetrahedron Letters

EngineeringBiochemistryNatural SciencesSingle Electron TransferRadical (Chemistry) +5

A convergent synthesis approach towards CGP60536B, a non-peptide orally potent renin inhibitor, via an enantiomerically pure ketolactone intermediate

H. Rüeger, Stefan Stutz, Richard Göschke, +2

Tetrahedron Letters

Combinatorial ChemistryBioorganic ChemistryBiochemistryMedicineNatural Sciences +6

Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors

Vittorio Rasetti, N.C. Cohen, H. Rüeger, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +10

Evaluation of a potent inhibitor of subprimate and primate renins.

J M Wood, Seng Chin Mah, Hans‐Peter Baum, +4

Journal of Pharmacology and Experimental Therapeutics