Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette M. Wood, Jürgen Maibaum, Joseph Rahuel, +19

Biochemical and Biophysical Research Communications

Combinatorial ChemistryPharmaceutical ScienceBiochemistryMedicineRational Drug Design +5

Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond

Mark C. Allen, Walter Fuhrer, B. Tuck, +2

Journal of Medicinal Chemistry

Pharmaceutical ScienceAmino Phosphorus DerivativesRenin InhibitorsPharmacotherapyScissile Leu-val Bond +15

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

Joseph Rahuel, Vittorio Rasetti, Jürgen Maibaum, +8

Chemistry & Biology

Drug TargetBiochemistryDrug DesignActive InhibitorsMedicine +9

Ortho functionalization of aromatic amines: ortho lithiation of N-pivaloylanilines

Walter Fuhrer, Heinz W. Gschwend

The Journal of Organic Chemistry

Molecular SciencesChemical AnalysisAltmetric Attention ScoreChemometricsAromatic Amines +7

Synthesis and biological activity of some transition-state inhibitors of human renin

Peter Bühlmayer, Walter Fuhrer, Richard Göschke, +5

Journal of Medicinal Chemistry

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5( <i>S</i> )-Amino-4( <i>S</i> )-hydroxy-8-phenyl-octanecarboxamides:  The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Jürgen Maibaum, Stefan Stutz, Richard Göschke, +11

Journal of Medicinal Chemistry

Effects of a specific and long-acting renin inhibitor in the marmoset.

J.M. Wood, N Gulati, Peter Forgiarini, +2

Hypertension

Molecular PharmacologyLong-acting Renin InhibitorInhibitory ActivityMolecular PhysiologyBlood Pressure +13

Novel 2,7-Dialkyl-Substituted 5(<i>S</i>)-Amino-4(<i>S</i>)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin

Richard Göschke, Stefan Stutz, Vittorio Rasetti, +13

Journal of Medicinal Chemistry

HypertensionNovel 2,7-Dialkyl-substituted 5PharmacotherapyPharmaceutical ChemistryBlood Pressure +15

5-Methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4- dione (BA 41899): Representative of a Novel Class of Purely Calcium-Sensitizing Agents

Peter Herold, J. W. Herzig, P. Wenk, +7

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +14

A Variation of the Sulfide Contraction Procedure for Synthesis of Corrinoid Systems

Erwin Götschi, Walter Hunkeler, Hans‐Jakob Wild, +4

Angewandte Chemie International Edition in English

Chemical EngineeringEngineeringSulfide Contraction ProcedureCatalysisCorrinoid Systems +1