Concepedia

Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning

Rachel A. Silverstein, Nahye Kim, Ann-Sophie Kroell, Russell T. Walton, Justin Delano, Rossano Butcher, Martin Pačesa, Kathleen A. Christie, Leillani L. Ha, Ronald J. Meis,

Nature · 2025 · 61 citations · 86 references

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86

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31.4K citations · Full text

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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text

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Enzymatic assembly of DNA molecules up to several hundred kilobases

Daniel G. Gibson, Lei Young, Ray-Yuan Chuang et al. · Nature Methods · 2009 · 10.9K citations

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UMAP: Uniform Manifold Approximation and Projection

Leland McInnes, John Healy, Nathaniel Saul et al. · The Journal of Open Source Software · 2018 · 9.6K citations · Full text

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UCSF ChimeraX: Meeting modern challenges in visualization and analysis

Thomas D. Goddard, Conrad C. Huang, Elaine C. Meng et al. · Protein Science · 2017 · 5.8K citations · Full text

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