Concepedia

Impact of library input on the hit discovery rate in DNA-encoded chemical library selections

Sara Puglioli, Sebastian Oehler, Luca Prati, Jörg Scheuermann, Gabriele Bassi, Samuele Cazzamalli, Dario Neri, Nicholas Favalli

Chemical Science · 2023 · 10 citations · 27 references

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Concepts

Abstract

copies of each library member is required for the confident identification of nanomolar hits, using generally applicable methodologies.

References

27

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Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Philip A. Harris, Scott B. Berger, Jae Uk Jeong et al. · Journal of Medicinal Chemistry · 2017 · 475 citations · Full text

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Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

Aidan G. Gilmartin, Thomas Faitg, Mark C. Richter et al. · Nature Chemical Biology · 2014 · 208 citations

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