Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen

A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products

Mans Minekus, M. Smeets-Peeters, Annick Bernalier et al. · Applied Microbiology and Biotechnology · 1999 · 453 citations

Agriculture, Nutrition, Bioenergetics +14

In vitro - in vivo correlation: from theory to applications.

Jaber Emami · PubMed · 2006 · 321 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Comparison of five in vitro digestion models to in vivo experimental results: Lead bioaccessibility in the human gastrointestinal tract

Tom R. Van de Wiele, Agnes G. Oomen, Joanna Wragg et al. · Journal of Environmental Science and Health Part A · 2007 · 185 citations

Pharmacy, Nutrition, Nutritional Sciences +15

An Integrated Model for Determining Causes of Poor Oral Drug Absorption

Lawrence X. Yu · Pharmaceutical Research · 1999 · 184 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

David Ribnicky, Diana E. Roopchand, Andrew Oren et al. · Food Chemistry · 2013 · 177 citations

Agriculture, Food Science, Nutritional Sciences +17