Anti-fatigue effect of<i>Lepidium meyenii</i>Walp. (Maca) on preventing mitochondria-mediated muscle damage and oxidative stress<i>in vivo</i>and<i>vitro</i>

Abstract

in C2C12 skeletal muscle cells. ME-induced activation of energy metabolism in skeletal muscle might up-regulate mitochondrial biogenesis and function, thereby protecting against oxidative stress-induced damage. We concluded that the effects of Maca played a crucial role in the regulation of exercise-induced fatigue in mouse muscle, which could be expected to serve as a functional food supplement for improving exercise performance and alleviating physical fatigue.