Edward T. Chouchani

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude et al. · Nature · 2014 · 2.7K citations · Full text

Inflammation, Mitochondrial Function, Biochemistry +9

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.7K citations · Full text

Inflammation, Reductive Stress, Anti-inflammatory +10

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Edward T. Chouchani, Carmen Methner, Sergiy M. Nadtochiy et al. · Nature Medicine · 2013 · 606 citations · Full text

Cysteine Switch, Mitochondrial Function, Biochemistry +8

Accumulation of succinate controls activation of adipose tissue thermogenesis

Evanna L. Mills, Kerry A. Pierce, Mark P. Jedrychowski et al. · Nature · 2018 · 528 citations · Full text

Energy Metabolism, Biochemistry, Physiology +6

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

Edward T. Chouchani, Lawrence Kazak, Mark P. Jedrychowski et al. · Nature · 2016 · 443 citations · Full text

Energy Metabolism, Mitochondrial Function, Biochemistry +8