Efficient synthesis of 5-alkyl amino and thioether substituted pyrazoles

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fused pyrimidines by a tandem aza-Wittig/electrocyclic ring closure strategy: synthesis of pyrazolo[3,4-d]pyrimidine, [1,2,3]triazolo[4,5-d]pyrimidine, and thiazolo[4,5-d]pyrimidine derivatives

Pedro Molina, Antonio Arques, Jan Becher et al. · The Journal of Organic Chemistry · 1988 · 68 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor

Y. LEBLANC, Patrick Roy, S. Boyce et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +4

Synthesis and ¹³C NMR of (trifluoromethyl)hydroxypyrazoles

Len F. Lee, F. M. SCHLEPPNIK, Ronald W. Schneider et al. · Journal of Heterocyclic Chemistry · 1990 · 41 citations

Natural Sciences, Chemistry, Organic Chemistry +4

Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors

Cheuk K. Lau, Christine Brideau, Chi Chung Chan et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10