From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

W. Cameron Black, Christopher I. Bayly, Michel Belley, +19

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAnti-inflammatorySelective Cox-2 InhibitorBiochemistryMedicine +9

Temporally distinct accumulation of transcripts encoding enzymes of the prechorismate pathway in elicitor-treated, cultured tomato cells.

J Görlach, Hanns -R. Raesecke, Doris Rentsch, +7

Proceedings of the National Academy of Sciences

Plant PhysiologyEngineeringPrechorismate PathwayPlant Defense GeneGenetics +16

The Interaction of Arginine 106 of Human Prostaglandin G/H Synthase-2 with Inhibitors Is Not a Universal Component of Inhibition Mediated by Nonsteroidal Anti-inflammatory Drugs

Gillian Greig, Donna A. Francis, Jean‐Pierre Falgueyret, +6

Molecular Pharmacology

Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2

Y. LEBLANC, W. Cameron Black, Chi-Chung Chan, +20

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicinePharmacotherapyCyclooxygenase 1 +6

The development of potent non-peptidic PTP-1B inhibitors

Claude Dufresne, Patrick Roy, Zhaoyin Wang, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePeptoidPharmacotherapyPharmacology +2

Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival

Stéphanie St‐Pierre, Wei Jiang, Patrick Roy, +5

PLoS ONE

Inflammatory Lung DiseaseLung InflammationImmunologyImmune RegulationCell Death +23

Infiltration of CCR2+Ly6Chigh Proinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis

Wei Jiang, Stéphanie St‐Pierre, Patrick Roy, +3

The Journal of Immunology

Synthetic studies on the mevinic acids using the chiron approach: total synthesis of (+)-dihydromevinolin

Stephen Hanessian, Patrick Roy, Marino Petrini, +3

The Journal of Organic Chemistry

Molecular SciencesEngineeringChemical MeasurementBiochemistryChemical Analysis +12

A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles

Patrick Roy, Y. LEBLANC, Richard G. Ball, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmacologyPharmacological AgentPharmacotherapyNew Series +4

The Structure of PTP-1B in Complex with a Peptide Inhibitor Reveals an Alternative Binding Mode for Bisphosphonates

Ernest Asante‐Appiah, Sangita B. Patel, Claude Dufresne, +9

Biochemistry

Crystal StructureMolecular BiologyChemical BiologyPeptide Inhibitor RevealsPharmaceutical Chemistry +14