From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

Elizabeth A. Meade, William L. Smith, David L. DeWitt · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

Medicine, Biochemistry, Pharmacology +15

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

Nobuko Futaki, Satoru Takahashi, Motofumi Yokoyama et al. · Prostaglandins · 1994 · 833 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment

Colin Funk, Lena B. Funk, Matthew Kennedy et al. · The FASEB Journal · 1991 · 574 citations

Life Sciences, Biochemistry, Molecular Biology +17

Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.

M. Lecomte, Odette Laneuville, Chen Ji et al. · Journal of Biological Chemistry · 1994 · 370 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

Chi‐Chung Chan, S. Boyce, Christine Brideau et al. · Journal of Pharmacology and Experimental Therapeutics · 1995 · 314 citations

Medicine, Pharmacology, Clinical Pharmacology +13