In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats

Christine Brideau, Carlo van Staden, Chi Chung Chan

American Journal of Veterinary Research

The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

Yaël Mamane, Chi Chung Chan, Geneviève Lavallée, +9

Diabetes

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

Renata M. Oballa, Liette Belair, W. Cameron Black, +28

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyFatty Liver DiseaseTherapeutic WindowMetabolic Syndrome +16

2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

Richard W. Friesen, Christine Brideau, Chi Chung Chan, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryActive Cyclooxygenase-2 InhibitorsMedicineNatural Sciences +7

Pyridazinones as selective cyclooxygenase-2 inhibitors

Chun Sing Li, Christine Brideau, Chi Chung Chan, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacological Agent +6

The development of potent non-peptidic PTP-1B inhibitors

Claude Dufresne, Patrick Roy, Zhaoyin Wang, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePeptoidPharmacotherapyPharmacology +2

Preferential inhibition of human phosphodiesterase 4 by ibudilast

Zheng Huang, Susana Liu, Lei Zhang, +5

Life Sciences

Molecular PharmacologyAutoimmune DiseasePreferential InhibitionMedicineMechanism Of Action +3

Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor

Daniel Guay, Pierre Hamel, Marc Blouin, +14

Bioorganic & Medicinal Chemistry Letters

Inhibitory ActivityMedicinal ChemistryDrug TargetMedicineNatural Sciences +8

Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors

Richard W. Friesen, Daniel Dubé, Réjean Fortin, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacotherapyAnti-cancer Agent +4

Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors

Michel Thérien, Christine Brideau, Chi Chung Chan, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryBiochemistryMedicineNatural Sciences +8