Bryson Rast

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog

Subas M. Sakya, Kristin M. Lundy DeMello, Martha L. Minich et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 51 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Efficient synthesis of 5-alkyl amino and thioether substituted pyrazoles

Subas M. Sakya, Bryson Rast · Tetrahedron Letters · 2003 · 45 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

Jin Li, Kristin M. Lundy DeMello, Henry S. Cheng et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +5

5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers

Subas M. Sakya, Hengmiao Cheng, Kristin M. Lundy DeMello et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 35 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile

Subas M. Sakya, Xinjun Hou, Martha L. Minich et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 31 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13