Discovery of (<i>S</i>)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, John Litchfield, +41

Journal of Medicinal Chemistry

Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle

Jeffrey A. Pfefferkorn, Jihong Lou, Martha L. Minich, +14

Bioorganic & Medicinal Chemistry Letters

Unique Metabolic LiabilityBiochemistryMedicineMechanism Of ActionGlucokinase Activators +8

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Jeffrey W. Corbett, Kevin D. Freeman‐Cook, Richard L. Elliott, +21

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineDrug Development +7

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog

Subas M. Sakya, Kristin M. Lundy DeMello, Martha L. Minich, +18

Bioorganic & Medicinal Chemistry Letters

5-Alkylamino PyrazolesMolecular PharmacologyMedicinal ChemistryBiochemistryCanine Cox-2 Inhibitors +9

Synthesis of compounds designed to inhibit bacterial cell wall transglycosylation

Scott J. Hecker, Martha L. Minich, Karen Lackey

The Journal of Organic Chemistry

Bioorganic ChemistryEngineeringAltmetric Attention ScoreJ. OrgAntimicrobial Chemotherapy +17

Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors

Hengmiao Cheng, Kristin M. Lundy DeMello, Jin Li, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineHeteroaryl-phenyl-substituted Pyrazole DerivativesPharmacological AgentPharmacotherapy +7

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

Jin Li, Kristin M. Lundy DeMello, Henry S. Cheng, +25

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceMedicinePharmacological AgentPharmacotherapy +5

Beta subunit copurifies with GppNHp-activated adenylyl cyclase.

Irith Marbach, Allan Bar-Sinai, Martha L. Minich, +1

Journal of Biological Chemistry

Beta Subunit CopurifiesMolecular PharmacologySignal TransductionMolecular PhysiologyBiochemistry +10

5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers

Subas M. Sakya, Hengmiao Cheng, Kristin M. Lundy DeMello, +18

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistry5-Heteroatom-substituted PyrazolesCanine Cox-2 Inhibitors +9

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile

Subas M. Sakya, Xinjun Hou, Martha L. Minich, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryPart IiiCanine Cox-2 InhibitorsMedicine +10