Concepedia

Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle

Jeffrey A. Pfefferkorn, Jihong Lou, Martha L. Minich, Kevin J. Filipski, Mingying He, Ru Zhou, Syed Ahsanuddin Ahmed, John W. Benbow, Angel-Guzman Perez, Meihua Tu,

Bioorganic & Medicinal Chemistry Letters · 2009 · 80 citations · 20 references

DOIFull text

Open access

Concepts

References

20

Global Prevalence of Diabetes

Sarah H. Wild, Gojka Roglić, Anders Green et al. · Diabetes Care · 2004 · 15.3K citations

, , +12

Insulin signalling and the regulation of glucose and lipid metabolism

Alan R. Saltiel, C. Ronald Kahn · Nature · 2001 · 5.3K citations · Full text

, , +14

A mild, general method for conversion of esters to amides

Anwer Basha, Michael F. Lipton, Steven M. Weinreb · Tetrahedron Letters · 1977 · 560 citations

, , +3

Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett et al. · Science · 2003 · 537 citations

, , +17

Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central Neurons

Ambrose A. Dunn-Meynell, Vanessa H. Routh, Ling Kang et al. · Diabetes · 2002 · 308 citations · Full text

, , +11