Insulin signalling and the regulation of glucose and lipid metabolism

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations

Signal Transduction, Molecular Physiology, Biochemistry +10

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Toshimasa Yamauchi, Junji Kamon, Hironori Waki et al. · Nature Medicine · 2001 · 4.9K citations

Insulin Resistance, Metabolic Syndrome, Obesity +11

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Jeffrey L. Halaas, K.S. Gajiwala, Margherita Maffei et al. · Science · 1995 · 4.4K citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Dario R. Alessi, Stephen R. James, C. Peter Downes et al. · Current Biology · 1997 · 2.8K citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +11

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations