Jihong Lou

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Robert L. Hoffman, Robert S. Kania, Mary A. Brothers et al. · Journal of Medicinal Chemistry · 2020 · 533 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +15

Pyridones as glucokinase activators: Identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle

Jeffrey A. Pfefferkorn, Jihong Lou, Martha L. Minich et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 80 citations · Full text

Life Sciences, Biochemistry, Pharmacology +10

Steady-State and Pre-Steady-State Kinetic Evaluation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL^pro Cysteine Protease:  Development of an Ion-Pair Model for Catalysis

James Solowiej, James A. Thomson, Kevin Ryan et al. · Biochemistry · 2008 · 49 citations

Life Sciences, Biochemistry, Molecular Biology +17

Partial Agonist Activity of 11-cis-Retinal in Rhodopsin Mutants

May Han, Jihong Lou, Koji Nakanishi et al. · Journal of Biological Chemistry · 1997 · 42 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Absolute Sense of Twist of the C12C13 Bond of the Retinal Chromophore in Bovine Rhodopsin Based on Exciton‐Coupled CD Spectra of 11,12‐Dihydroretinal Analogues

Qiang Tan, Jihong Lou, Babak Borhan et al. · Angewandte Chemie International Edition in English · 1997 · 30 citations

Medicine, Biophysics, Vision Science +16