Concepedia

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog

Subas M. Sakya, Kristin M. Lundy DeMello, Martha L. Minich, Bryson Rast, Andrei Shavnya, Robert J. Rafka, David A. Koss, Hengmiao Cheng, Jin Li, Burton H. Jaynes,

Bioorganic & Medicinal Chemistry Letters · 2005 · 51 citations · 15 references

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References

15

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

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Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs

M C Allison, Allan G. Howatson, Caroline J. Torrance et al. · New England Journal of Medicine · 1992 · 962 citations · Full text

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Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

Odette Laneuville, D.K. Breuer, David L. DeWitt et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 472 citations

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In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats

Christine Brideau, Carlo van Staden, Chi Chung Chan · American Journal of Veterinary Research · 2001 · 210 citations · Full text

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Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

Gary P. O’Neill, Joseph A. Mancini, Stacia Kargman et al. · Molecular Pharmacology · 1994 · 183 citations

, , +13