Concepedia

Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling

Samuel J. Tong, Adam A. Wall, Yu Hung, Lin Luo, Jennifer L. Stow

Small GTPases · 2019 · 23 citations · 43 references

DOIFull text

Open access

Concepts

Abstract

TLR: Toll-like Receptor; OCRL: oculocerebrorenal syndrome of Lowe protein; PI3Kγ: phosphoinositol-3-kinase gamma; LPS: lipopolysaccharide; GEF: guanine nucleotide exchange factor; GST: glutathione S-transferases; BMMs: bone marrow derived macrophages; PH: pleckstrin homology; GAP: GTPase activating protein; ABCA1: ATP binding cassette subfamily A member 1; GDI: GDP dissociation inhibitor; LRP1: low density lipoprotein receptor-related protein 1.

References

43

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

, , +15

A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Greg M. Delgoffe, Kristen Pollizzi, Adam T. Waickman et al. · Nature Immunology · 2011 · 1.1K citations · Full text

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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau, Matthew Rausch, David A. Winkler et al. · Nature · 2016 · 865 citations

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

Alfonso Bellacosa, Tung O. Chan, Naheed N. Ahmed et al. · Oncogene · 1998 · 542 citations

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