Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Lin Luo, Adam A. Wall, Jeremy C. Yeo, +11

Nature Communications

Tlr4-driven Pi3kSignal TransductionSignaling PathwayMolecular RegulationNatural Sciences +8

Macropinosome formation by tent pole ruffling in macrophages

Nicholas D. Condon, John M. Heddleston, Teng-Leong Chew, +6

The Journal of Cell Biology

Signal TransductionCell SignalingMedicineNatural SciencesAutophagy +13

TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses

Lin Luo, Adam A. Wall, Samuel J. Tong, +7

Cell Reports

Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors

Adam A. Wall, Lin Luo, Yu Hung, +5

Journal of Biological Chemistry

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

Lin Luo, Nilesh J. Bokil, Adam A. Wall, +11

Nature Communications

Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages

Amanda C. Stanley, Zi Zhao Lieu, Adam A. Wall, +5

Journal of Leukocyte Biology

ImmunologyImmune RegulationLps-activated MacrophagesImmunologic MechanismInnate Immunity +18

Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages

Jeremy C. Yeo, Adam A. Wall, Lin Luo, +1

Molecular Biology of the Cell

Innate Immune SystemImmunologyImmune RegulationCell DeathImmunologic Mechanism +18

Formation of retromer transport carriers is disrupted by the Parkinson disease‐linked Vps35 <scp>D620N</scp> variant

Yi Cui, Zhe Yang, Neftali Flores‐Rodriguez, +5

Traffic

Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes

Adam A. Wall, Nicholas D. Condon, Lin Luo, +1

Philosophical Transactions of the Royal Society B Biological Sciences

Tlr SignallingMicrobial PathogensInnate Immune SystemImmunologyImmune Regulation +19

Sequential recruitment of Rab GTPases during early stages of phagocytosis

Jeremy C. Yeo, Adam A. Wall, Lin Luo, +1

Cellular Logistics

Innate Immune SystemImmunologyCell DeathImmunologic MechanismInnate Immunity +14