Greg M. Delgoffe

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

Greg M. Delgoffe, Thomas P. Kole, Yan Zheng et al. · Immunity · 2009 · 1.2K citations · Full text

Signal Transduction, Cell Regulation, Signaling Pathway +9

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson, Paolo Vignali, Steven J. Mullett et al. · Nature · 2021 · 1.1K citations · Full text

Cancer Immunosurveillance, T-regulatory Cell, Immunology +6

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Greg M. Delgoffe, Kristen Pollizzi, Adam T. Waickman et al. · Nature Immunology · 2011 · 1.1K citations · Full text

Kinase Mtor, Signal Transduction, Signaling Pathway +8

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

Bertram Bengsch, Andrew L. Johnson, Makoto Kurachi et al. · Immunity · 2016 · 775 citations · Full text

Metabolic Alterations, Bioenergetic Insufficiencies Due, Signal Transduction +15

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk et al. · Nature Immunology · 2021 · 760 citations · Full text

Continuous Stimulation, Mitochondrial Function, Mitochondrial Dynamic +12