Nicole E. Scharping

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk et al. · Nature Immunology · 2021 · 760 citations · Full text

Continuous Stimulation, Mitochondrial Function, Mitochondrial Dynamic +12

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Nicole E. Scharping, Ashley V. Menk, Rebecca S. Moreci et al. · Immunity · 2016 · 744 citations · Full text

Cancer Immunosurveillance, Oncology, Mitochondrial Biogenesis +7

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

Nicole E. Scharping, Ashley V. Menk, Ryan D. Whetstone et al. · Cancer Immunology Research · 2016 · 497 citations · Full text

Metformin Monotherapy, Pd-1 Blockade, Immunology +19

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

Ashley V. Menk, Nicole E. Scharping, Rebecca S. Moreci et al. · Cell Reports · 2018 · 466 citations · Full text

Adaptive Immune System, Immunology, Immunologic Mechanism +22

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

Ashley V. Menk, Nicole E. Scharping, Dayana B. Rivadeneira et al. · The Journal of Experimental Medicine · 2018 · 291 citations · Full text