The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih‐Hao Chang, Jing Qiu, David O’Sullivan et al. · Cell · 2015 · 3.2K citations · Full text

Medicine, Cancer Biology, Oncology +16

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Jeong Kim, Jeffrey P. Rasmussen, Alexander Y. Rudensky · Nature Immunology · 2006 · 1.8K citations

Life Sciences, Genetics, Immunology +14

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

Seng‐Ryong Woo, Meghan E. Turnis, Monica V. Goldberg et al. · Cancer Research · 2011 · 1.6K citations · Full text

Life Sciences, Immunology, Oncology +17

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

Gerritje J. W. van der Windt, Bart Everts, Chih‐Hao Chang et al. · Immunity · 2011 · 1.5K citations · Full text

Life Sciences, Cell Biology, Immunology +14

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ping‐Chih Ho, Jessica Bihuniak, Andrew N. Macintyre et al. · Cell · 2015 · 1.4K citations · Full text

Life Sciences, Biochemistry, Oncology +14