McLane J. Watson

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson, Paolo Vignali, Steven J. Mullett et al. · Nature · 2021 · 1.1K citations · Full text

Cancer Immunosurveillance, T-regulatory Cell, Immunology +6

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

Roberta Zappasodi, Inna Serganova, Ivan Cohen et al. · Nature · 2021 · 373 citations · Full text

Cancer Immunosurveillance, Oncology, Medicine +9

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

Ashley V. Menk, Nicole E. Scharping, Dayana B. Rivadeneira et al. · The Journal of Experimental Medicine · 2018 · 291 citations · Full text

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity

Paolo Vignali, Kristin DePeaux, McLane J. Watson et al. · Nature Immunology · 2022 · 235 citations · Full text

Cancer Immunosurveillance, T-regulatory Cell, Immunology +8

Carbon source availability drives nutrient utilization in CD8+ T cells

Irem Kaymak, Katarzyna M. Luda, Lauren R. Duimstra et al. · Cell Metabolism · 2022 · 135 citations · Full text