Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau, Matthew Rausch, David A. Winkler, +21

Nature

Hematological MalignancyBlockade TherapyImmunologyImmune Checkpoint InhibitorMyeloid Cells +5

T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

Daniel Hirschhorn, Sadna Budhu, Lukas Kraehenbuehl, +31

Cell

Tumor ImmunologyCancer ImmunosurveillanceAutoimmune DiseaseImmunologyTumor Immunity +9

Mouse ChemR23 Is Expressed in Dendritic Cell Subsets and Macrophages, and Mediates an Anti-Inflammatory Activity of Chemerin in a Lung Disease Model

Souphalone Luangsay, Valérie Wittamer, Benjamin Bondue, +7

The Journal of Immunology

Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2

Olivier De Henau, Gaetan-Nagim Degroot, Virginie Imbault, +6

PLoS ONE

Chemokine BiologyChemerin Receptors Cmklr1Chemerin 9Chemical BiologyMolecular Pharmacology +15

ChemR23 Dampens Lung Inflammation and Enhances Anti-viral Immunity in a Mouse Model of Acute Viral Pneumonia

Benjamin Bondue, Olivier Vosters, Patricia de Nadaı̈, +8

PLoS Pathogens

Acute Lung InjuryInflammatory Lung DiseaseLung InflammationImmunologyImmunologic Mechanism +15

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

Sadna Budhu, Rachel Giese, Aditi Gupta, +13

Cell Reports

The Chemerin/ChemR23 System Does Not Affect the Pro-Inflammatory Response of Mouse and Human Macrophages Ex Vivo

Benjamin Bondue, Olivier De Henau, Souphalone Luangsay, +5

PLoS ONE

Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade

Arnab Ghosh, Judith Michels, Riccardo Mezzadra, +24

Journal of Clinical Investigation

ImmunologyImmune Checkpoint BlockadeImmunotherapyCancer BiologyTumor Biology +14

Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer

Theodore J. Sanders, Christopher S. Nabel, Margreet Brouwer, +17

Nature Immunology

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Casey R. Ager, Matthew J. Reilley, Courtney Nicholas, +275

Journal for ImmunoTherapy of Cancer