Toll-like Receptors - Concepedia

About

Toll-like receptors is a class of transmembrane proteins serving as pattern recognition receptors (PRRs) within the innate immune system, crucial for detecting conserved molecular structures associated with pathogens (PAMPs) or host damage (DAMPs) and initiating downstream signaling cascades that orchestrate inflammatory and adaptive immune responses.

Top Publications

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A Toll-like receptor recognizes bacterial DNA	2000
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3	2001
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity	1997
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses	2006
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis	2004