Tung O. Chan

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Thomas Franke, Sung‐Il Yang, Tung O. Chan et al. · Cell · 1995 · 2K citations · Full text

Akt Proto-oncogene, Signal Transduction, Signaling Pathway +11

Akt activation by growth factors is a multiple-step process: the role of the PH domain

Alfonso Bellacosa, Tung O. Chan, Naheed N. Ahmed et al. · Oncogene · 1998 · 539 citations

Signal Transduction, Signaling Pathway, Cell Regulation +13

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

Naheed N. Ahmed, H. Leighton Grimes, Alfonso Bellacosa et al. · Proceedings of the National Academy of Sciences · 1997 · 525 citations · Full text

Apoptosis, Immunology, Cell Death +17

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

W G King, Mark D. Mattaliano, Tung O. Chan et al. · Molecular and Cellular Biology · 1997 · 430 citations · Full text

Phosphatidylinositol 3-Kinase, Integrin-mediated Adhesion, Cellular Physiology +16

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

Ketaki Datta, Alfonso Bellacosa, Tung O. Chan et al. · Journal of Biological Chemistry · 1996 · 277 citations · Full text