Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, +4

Cell

Tissue EngineeringRegenerative MedicineDefined FactorsEmbryonic Stem CellDevelopmental Biology +12

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

Laurie A. Boyer, Tong Ihn Lee, Megan F. Cole, +11

Cell

Transcriptional RegulationDevelopmental BiologyMedicineAdult Stem CellStem Cell Research +4

Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells

Shinji Masui, Yuhki Nakatake, Yayoi Toyooka, +9

Nature Cell Biology

Embryonic Stem CellInduced Pluripotent Stem CellDevelopmental BiologyOct3/4 ExpressionCell Specialization +6

Dissecting self-renewal in stem cells with RNA interference

Natalia Ivanova, Radu Dobrin, Rong Lu, +6

Nature

MedicineAdult Stem CellStem Cell ResearchStem CellsCell Biology +1

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Jing Wang, Sarah Hevi, Julia K. Kurash, +10

Nature Genetics

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsDna Methylation +8

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

Katrin Arnold, Abby Sarkar, Mary Anna Yram, +6

Cell stem cell

Progenitor CellsRegenerative MedicineInduced Pluripotent Stem CellDevelopmental BiologyMedicine +9

Reciprocal Transcriptional Regulation of <i>Pou5f1</i> and <i>Sox2</i> via the Oct4/Sox2 Complex in Embryonic Stem Cells

Joon-Lin Chew, Yuin‐Han Loh, Wensheng Zhang, +8

Molecular and Cellular Biology

GeneticsStem Cell BiologyCell SpecializationHuman EscsTranscriptional Regulation +17

A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1

Jianping Jin, Emily E. Arias, Jing Chen, +2

Molecular Cell

Protein FunctionReplication Factor Cdt1Natural SciencesMolecular BiologyDna Replication +6

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Luca A. Lotta, Pawan Gulati, Felix R. Day, +27

Nature Genetics

Insulin ResistanceMetabolic SyndromeObesityMetabolic DisorderGenetics +8

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

Mubeen Goolam, Antonio Scialdone, Sarah J. L. Graham, +6

Cell