Concepedia

Protein Turnover

Protein Turnover is the continuous metabolic process by which proteins are synthesized and subsequently degraded within cells, maintaining cellular function and amino acid homeostasis.

7.8K

Publications

587.5K

Citations

25.1K

Authors

3.5K

Institutions

Publications per year

2017–2026

717

Parents

Children

Publications

7.8K

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

Scott W. Rogers, Rodney Wells, Martin Rechsteiner · Science · 1986 · 2.6K citations

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Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

, , +17

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

Andreas Bachmair, Daniel Finley, Alexander Varshavsky · Science · 1986 · 2K citations

, , +14

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

Heather P. Harding, Yuhong Zhang, Anne Bertolotti et al. · Molecular Cell · 2000 · 2K citations · Full text

, , +15

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

Kevin Travers, Christopher K. Patil, Lisa Wodicka et al. · Cell · 2000 · 2K citations · Full text

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1–5 of 7.8K

Authors

25.1K

  1. AL
    Alfred L. Goldberg

    Harvard University, United States

    107 publications · 17.7K citations

    75

    h-index

  2. AC
    Aaron Ciechanover

    Technion – Israel Institute of Technology, Israel

    62 publications · 6.1K citations

    39

    h-index

  3. AV
    Alexander Varshavsky

    California Institute of Technology, United States

    36 publications · 11.4K citations

    34

    h-index

  4. PG
    P.J. Garlick

    University of Aberdeen, United Kingdom

    36 publications · 5.2K citations

    29

    h-index

  5. JF
    J. Fred Dice

    Tufts University, United States

    36 publications · 4.7K citations

    29

    h-index

1–5 of 25.1K

Institutions

3.5K

  1. Harvard University

    Cambridge, United States

    111 h-index

    858 publications

    124.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    59 h-index

    192 publications

    44.3K citations

  3. National Institutes of Health

    Bethesda, United States

    54 h-index

    283 publications

    36.1K citations

  4. Technion – Israel Institute of Technology

    Haifa, Israel

    50 h-index

    278 publications

    28.5K citations

  5. Pennsylvania State University

    State College, United States

    47 h-index

    263 publications

    23.3K citations

  6. University of California, San Francisco

    San Francisco, United States

    47 h-index

    225 publications

    36.4K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    46 h-index

    399 publications

    28.9K citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    44 h-index

    198 publications

    37.1K citations

1–8 of 3.5K

Venues

  1. Journal of Biological Chemistry

    JBC · 865 publications · 85.3K citations

    153

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 215 publications · 32.2K citations

    98

    h-index

  3. Biochemistry

    182 publications · 15.5K citations

    67

    h-index

  4. Biochemical Journal

    BJ · 256 publications · 15.3K citations

    65

    h-index

  5. 65

    h-index

1–5