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Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

Heather P. Harding, Yuhong Zhang, Anne Bertolotti, Huiqing Zeng, David Ron

Molecular Cell · 2000 · 2K citations · 19 references

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19

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

Heather P. Harding, Yuhong Zhang, David Ron · Nature · 1999 · 3.3K citations

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Toshiyuki Nakagawa, Hong Zhu, Nobuhiro Morishima et al. · Nature · 2000 · 3.3K citations

, , +12

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti et al. · Science · 2000 · 3K citations

, , +16

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

Yasunori Kozutsumi, Mark S. Segal, Karl Normington et al. · Nature · 1988 · 1.3K citations

, , +12

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

Jeffery S. Cox, Caroline E. Shamu, Peter Walter · Cell · 1993 · 1.2K citations

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