Salvador Alejo

Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase

Feng Leng, Jiekai Yu, Chunxiao Zhang et al. · Nature Communications · 2018 · 62 citations · Full text

Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase

Chunxiao Zhang, Feng Leng, Lovely Saxena et al. · Journal of Biological Chemistry · 2018 · 50 citations · Full text

Protein Function, Methylated Sox2 Protein, Molecular Regulation +8

KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer

Mei Zhou, Prabhakar Pitta Venkata, Suryavathi Viswanadhapalli et al. · Breast Cancer Research and Treatment · 2020 · 48 citations

Breast Oncology, Medicine, Stem Cells +12

LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase–dependent proteolysis of the stem-cell protein SOX2

Chunxiao Zhang, Nam Hoang, Feng Leng et al. · Journal of Biological Chemistry · 2018 · 45 citations · Full text

Systems Biology, Epigenetic Regulation, Stem-cell Protein Sox2 +11

Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma

Salvador Alejo, Bridgitte E. Palacios, Prabhakar Pitta Venkata et al. · Neuro-Oncology · 2023 · 43 citations · Full text