Concepedia

Ubiquitin System

The Ubiquitin System is a eukaryotic protein regulatory machinery that selectively targets substrate proteins for degradation or modification through the covalent attachment of ubiquitin molecules, thereby distinguishing itself from other post-translational regulatory systems by its specificity in marking proteins for proteasomal processing or functional alteration.

8.5K

Publications

724.5K

Citations

38K

Authors

4.3K

Institutions

Publications per year

2017–2026

2.2K

Parents

Publications

8.5K

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

Sue C. Bodine, Esther Latres, Susanne Baumhueter et al. · Science · 2001 · 3.5K citations · Full text

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β‐catenin is a target for the ubiquitin–proteasome pathway

Hermann Aberle, Andreas Bauer, Jörg Stappert et al. · The EMBO Journal · 1997 · 2.5K citations

, , +7

Cyclin is degraded by the ubiquitin pathway

Michael Glotzer, Andrew W. Murray, Marc W. Kirschner · Nature · 1991 · 2.4K citations

, , +6

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg et al. · Cell · 1994 · 2.1K citations

, , +11

A ubiquitin-like system mediates protein lipidation

Yoshinobu Ichimura, Takayoshi Kirisako, Toshifumi Takao et al. · Nature · 2000 · 2K citations

, , +14

1–5 of 8.5K

Authors

38K

  1. AC
    Aaron Ciechanover

    Technion – Israel Institute of Technology, Israel

    105 publications · 11.6K citations

    59

    h-index

  2. AV
    Alexander Varshavsky

    California Institute of Technology, United States

    56 publications · 15.7K citations

    50

    h-index

  3. KT
    Keiji Tanaka

    Tokyo Metropolitan Institute of Medical Science, Japan

    72 publications · 9.2K citations

    48

    h-index

  4. RD
    Richard D. Vierstra

    University of Wisconsin–Madison, United States

    56 publications · 6K citations

    43

    h-index

  5. BA
    Brenda A. Schulman

    St. Jude Children's Research Hospital, United States

    53 publications · 7.7K citations

    40

    h-index

1–5 of 38K

Institutions

4.3K

  1. Harvard University

    Cambridge, United States

    132 h-index

    1.2K publications

    232.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    112 h-index

    579 publications

    126K citations

  3. National Institutes of Health

    Bethesda, United States

    81 h-index

    628 publications

    79.4K citations

  4. Johns Hopkins University

    Baltimore, United States

    73 h-index

    421 publications

    53.6K citations

  5. University of Toronto

    Toronto, Canada

    70 h-index

    633 publications

    65.7K citations

  6. Technion – Israel Institute of Technology

    Haifa, Israel

    68 h-index

    597 publications

    57.6K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    66 h-index

    745 publications

    50.2K citations

  8. California Institute of Technology

    Pasadena, United States

    63 h-index

    265 publications

    45.7K citations

1–8 of 4.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 1.1K publications · 108.9K citations

    168

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 339 publications · 45.6K citations

    128

    h-index

  3. Molecular Cell

    164 publications · 32K citations

    102

    h-index

  4. The EMBO Journal

    143 publications · 24.7K citations

    88

    h-index

  5. Molecular and Cellular Biology

    MCB · 171 publications · 19.2K citations

    82

    h-index

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