MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

Hong Sun, Catherine H. Charles, Lester F. Lau, +1

Cell

Signal TransductionSignaling PathwayCell RegulationNatural SciencesMolecular Biology +8

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

Dongmei Li, Hong Sun

PubMed

Molecular BiologyCytoskeletonTumor BiologySignaling PathwayCell Regulation +14

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

Hong Sun, Ralf Lesche, Daming Li, +7

Proceedings of the National Academy of Sciences

Phosphatidylinositol 3,4,5Cell DeathCell ProliferationCell CyclePten Deficiency +19

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G ₁ cell cycle arrest in human glioblastoma cells

Daming Li, Hong Sun

Proceedings of the National Academy of Sciences

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

Jeremy Minshull, Hong Sun, Nicholas K. Tonks, +1

Cell

ChromatinCell RegulationCell DivisionNatural SciencesDna Replication +9

CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

Leigh Ann Higa, Min Wu, Ye Tao, +3

Nature Cell Biology

Histone ModificationsChromatinTranscriptional RegulationChromatin StructureChromatin Remodeling +13

Cre/<i>loxP</i>‐mediated inactivation of the murine <i>Pten</i> tumor suppressor gene

Ralf Lesche, Matthias Groszer, Jing Gao, +5

genesis

MedicineCancer Cell BiologyTumor SuppressorCancer BiologyCell Biology +2

PTEN affects cell size, cell proliferation and apoptosis during <i>Drosophila</i> eye development

He Huang, Christopher J. Potter, Wufan Tao, +5

Development

CAND1 Binds to Unneddylated CUL1 and Regulates the Formation of SCF Ubiquitin E3 Ligase Complex

Jian‐Yu Zheng, Xiaoming Yang, Jennifer M. Harrell, +7

Molecular Cell

Transcriptional RegulationCand1 BindsProtein FunctionUnneddylated Cul1Cell Regulation +10

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

Joanna Liliental, Sun Young Moon, Ralf Lesche, +5

Current Biology

Signal TransductionSignaling PathwayCell RegulationGenetic DeletionMedicine +9