Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity

Publication | Open Access

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References

2017

Year

Hua Gong, David S. Weinstein, Zhonghui Lu, James J.‐W. Duan, Sylwia Stachura, Lauren Haque, Hemalatha Hemagiri, Dhanya Kumar Raut, Arun Kumar Gupta, Javed Khan,

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPregnane X ReceptorBiochemistryFunctional SelectivityMedicineInverse AgonistsStructure-based Drug DesignMechanism Of ActionReceptor (Biochemistry)Experimental PharmacologyPharmacotherapyPharmacologyDrug Discovery